The device developed during the MEAZURE project will provide new opportunities for in vitro compound testing. It will give in one-step several information on each individual well: the effect on the Blood-Brain Barrier (BBB and the effect on the neural tissue integrating BBB restrictions).

This monitoring in real-time will give extra value to the data, since it will allow to perform kinetic analysis. Similarly to existing BBB models, MEAZURE’s device will allow to assess the BBB permeability and to perform transport experiments in order to determine the pharmacokinetic of the tested molecules.

Finally, the integration of the neural model combined with MEA-recordings will give additional physiological relevant information on effects at the neuronal level.


Luc Stoppini

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